Samphire Neuroscienceレビュー 

I followed Samphire Neuroscience on social media since December 2023. I'd noticed in 2022, after coming off medication for my mental health, that my anxiety peaked significantly in the week leading up to my period. I would barely sleep, I was constantly on edge and my mind was constantly on overdrive. I was also really emotional, but as soon as my period started it was like a switch flipped and I was back to myself. I spoke to my doctor about this who suggested going back on antidepressants, however for 3 weeks out of 4 of the month, I was doing better than ever, so I didn't want to pursue this unless as a last resort. I kept thinking about trying the Nettle device, however the price put me off.

In March 2026, I finally bit the bullet and purchased the Nettle headband. I half hoped it wouldn't work, given the cost, but I felt comfortable trying it given that I could return within 3 months if it didn't work for me. I've used the headband for 3 menstrual cycles now, and I genuinely feel like a different person. I no longer dread the luteal phase.

My mind feels so much quieter and more still since using this device. My emotions feel much more regulated, and my cramps have also reduced, which isn't something I actually anticipated. I use it for the week or so in the run up to my period, for 20 minutes a day, and I still can't believe something so simple has changed my life so much. Any anxious thoughts i do have no longer hold any weight.

I had to contact customer services due to having an issue with the app and they were really helpful and kept me informed throughout. I've had to re-order the sponges once and they arrived quickly too.

The headband just feels tingly whilst its in use. You get used to it quite quickly. I used the app for over a year before investing in Nettle and I absolutely love how useful it is, and the 6 month cycle report you can generate is so interesting. I love reviewing my own data.

I'm annoyed it took me so long to give this a try. I've seen amazing results in a short amount of time so I'm looking forward to seeing further progress. I know it's not cheap but its a worthwhile investment for your own peace.

I’ve just finished the second cycle with Nettle, and OH MY GOD?! I don’t remember the last time when I’ve had energy through the whole month and not just the first 10 days of the cycle. There were still some emotional moments, but the biggest difference I’ve noticed in terms of feeling energised and having strength to do things, keep up my hobbies, looking after the household. The support was amazing too, quickly replying to any questions and helping me receive refills from abroad. Life changing!! Totally recommend this as someone struggling with PMDD.

I’ve been using Lutea for 5-6 months now. The first cycle I noticed my mental health symptoms were lessened but still I was pretty wiped physically. The second month I was reducing my SSRI dose, so was a little bumpy as expected.
From there things improved each month. I recently added a very low dose of a new med and had my first PMDD free month in forever!! I always assumed I might need a combo of things, and this combo is a win for me.
I know many of us feel completely helpless in luteal. Lutea gives you hope and a sense of control. This alone was a huge benefit for me.
Thanks Samphire team, you are amazing! xx

Samphire and their Lutea device is amazing. It’s been transformational for my life, and their customer service is amazing. I’ve had nothing but positive experiences with their technology and team.

The Lutea has been game-changing for me. I struggle with complex chronic illness, and it's made a huge difference for me, from decreasing my vulvodynia and period pain, to reducing anxiety (so much so that I'm doing less therapy!), to increasing my focus and energy.

I'm very sensitive to medication, and am amazed by how effective Lutea is without side effects (other than minor tingling while using it, which I'd take over my symptoms any day!).

I used it during my egg freezing process, and it made a massive difference with that, too. My boyfriend and I both looked forward to when I'd use it each day. It significantly improved my energy and mood and reduced my pain, bloating, and headaches. It was like night and day during that process. I'm still using it 1-2 times a day now and couldn't recommend it more. Give it a try, you won't be disappointed!

Also, the staff have been incredibly responsive and supportive, too! Thank you!!!

I took my time to make the decision to purchase a headset. For a few months I researches the company and neuro stimulation. And I watched a webinar from the team explaining exactly how the technology worked (and asked my husband to watch along too!) and read the honest reviews from those who had experience. We made an informed decision together to try this and I'm so glad I did. I use the headset as part of my holistic management of PMDD which includes a low dose SSRI. I have been using the technology monthly for 7 months now and I can confirm that my bad days have reduced by at least 3 days so far from up to 2 weeks. I feel generally calmer and more myself in my luteal phase. Thank you for Em and Cat for all your help so far - I'm excited to hear more about this becoming an official treatment option!

I am almost through my first cycle using Lutea for PMDD and it’s already been life changing. I also have hEds, decompressed Chiari, ADHD and a few others but the PMDD has been the hardest to manage. So far-no blow out fights with my partner, no inescapable downward spirals, no SI and a large decrease in physical symptoms as well. I have tried all the pharmaceuticals with no improvement, I haven’t worked in years to focus solely on surviving my own body. I have been using antihistamines, supplements, staying active, eating clean, all the lifestyle changes that bring 1% relief with each change and the last 3 cycles before this felt like I wouldn’t make it to menopause as I’m only 36. This headband makes me feel like maybe I could be a functioning member of society before I turn 50 and I haven’t ever felt that way with everything else I have been doing. The only side effect is skin irritation and I could not be bothered to care because the mental relief in such a short amount of time is so substantial. I wander and read during the sessions to distract myself from the tingling so I’d call it mild discomfort. If you’ve tried everything without relief, try one last time with this 🫶

Samphire is an amazing woman-led company where everyone involved cares about what they do, and it shows. When I first bought my Lutea, I had some technical difficulties (thick hair) getting it to make contact, and after reaching out to the Samphire team, they gave me a ton of things to try, and even included videos to show easier ways for thick haired people to get their headbands to create contact more easily. They have always been insanely responsive and helpful. I also looooove the Samphire app and the way it allows for symptom tracking, medication tracking, and exporting data to share with providers (or just look at yourself) later on. It is incredible.

I'm on my fifth cycle of using Nettle and can honestly say it has made my luteal phase SO much easier. I was sceptical when I ordered the device and half-hoped it wouldn't work so I could get my money back – but it does work, and for me it has been well worth the money so far.

When it first arrived I found it difficult to get the sponges to connect. It still takes me two attempts to get the device fully connected, but it's pretty easy once you get used to it.

In terms of actual impact, before using Nettle I suffered from irritability, depression, fatigue and food cravings throughout luteal. During the first month of using Nettle, these symptoms were still present, but I began to see significant reductions in months 2 and 3. Now I only record 'mild' versions of these symptoms, and they occur much less frequently – around 1–4 days a month, versus 10 days a month prior to Nettle. I would estimate that my mental symptoms have decreased by 75%. This has made me feel more stable, has greatly benefited my relationships and has generally made it possible for me to go about life normally. It's honestly been amazing!

One caveat: I have a copper coil, so I experience bad cramps during my period. Nettle has reduced this pain, but only slightly – I would say it's more like a 25% reduction. I see the device has reduced pain for lots of other people, so I wonder if my situation is different because of the coil.

An interesting thing I've noticed is that when I use the device for 3 days of my period, it makes my period much lighter and shorter! I'm pretty happy with this side effect because the coil made my periods longer and heavier.

Overall, I would highly recommend Nettle to anyone suffering similar symptoms to me. I use it for two weeks every month, from around day 17 to around day 3. I'm so grateful to Samphire for paving the way in this under-researched area. I really hope they manage to get Nettle devices on the NHS to increase accessibility!

I have the Lutea. The app is immensely frustrating. I received the free subscription, I have a login and password but it keeps looping me back to pay for a subscription. Infuriating given that I just have these people close to $600 for something I cannot use because of a $60/month app. Hopefully it would be this difficult getting a refund!

Finally something that works. PMDD and endometriosis has been hell for years. Nettle has definitely reduced severity of symptoms. Worth it.

The headband is very easy to use and you can go about your day with it on. It's a little tickly at first but you get used to it. I've got pmdd and it's too early to tell if it's affecting my mood symptoms but I also have painful periods and cramps and I can't believe how much it's reduced my pain. Almost non existent pain now and the difference is crazy.

I have PMDD and my Lutea (Nettle) has been helping regulate my moods and energy levels.
Two months in and noticing a big difference.

This headband is a game changer. The example I’ll give, which most women with PMDD can relate to, is the feeling of being out of control of your emotions when tangled in a perceived conflict with your partner. These moments can get really intense, really fast, and one such situation presented itself in my first cycle using Lutea. I put the headband on and did a session when I was ruminating post conflict….and wow…within maybe 5 minutes I could see with such clarity what the miscommunication was, my role in it, and that it was in fact a storm in a teacup - that I was wasn’t seeing things clearly - and from that session I had regained my composure and agency to approach my partner with a whole heart and make things right. This was huge, and my first cycle was a lot less stressful than normal. I felt connected to my husband as a result. Mood regulation is so much better. I’m day 22 of the next cycle and started using the band yesterday at day 21 when things start to wobble. So far, so good. I love my Lutea!!

I work in women’s and mental health and using nettle has had the most significant impact on my PMDD related depression out of all other interventions I have tried. It is now something I recommend to clients. The team are always very responsive with any queries.

Nettle really helps me every month, and even knowing it's there as a tool for me makes a big difference. Sessions lift my mood and help me feel more in control of my mood and emotions. I've had it since September 25. The customer service is brilliant and I truly believe Samphire will be everywhere in 5 years, changing the game for even more women

Nettle helps me with my PMDS symptoms and makes everyday life much easier. Before Nettle, I was taking SSRIs, and on really bad days I would occasionally need a calming medication. Overall, I feel like I can control my emotions a little better now. There are fewer extremely bad days.
I use Nettle from ovulation until my period, so for quite a lot of days each month. At the beginning, I had an issue with the device, but the support team was very quick and truly excellent. I received a replacement right away and got immediate help.
Thank you for this wonderful invention! Nettle doesn’t cure my PMDS, but even the fact that it helps a little brings me so much relief. Thank you!

The Nettle has been life changing as someone with pcos and pmdd, and long term depression. It’s helped me to manage my mood and reduced my pain symptoms. It’s not like any other treatment I have experienced, with almost immediate lessening of my anxiety. After 9 months of use, I swear by it. It makes bad days much brighter and more manageable. I am so grateful to be able to experience this after years of struggling deeply. Thanks to the whole team. Great customer service too!

I've been using Nettle since May 2025, and it's given me real, felt relief from some of the psychological symptoms of my PMDD including anxiety, overwhelm, panic. The team is also amazingly responsive to questions/queries/feedback

Less crying, less snapping, just in general a more calm time before my periods. Between loosing weight and pre-menopause, my cycle has become notable longer than it used to be, and I'm so grateful that I don't have to spend that time waiting for my period and the calmer, more positive part of my cycle to begin. Or dreading the luteal phase, when my mood would start to dive.